Challenges to Data Monitoring Committees When Regulatory Authorities Intervene

Challenges to Data Monitoring Committees When Regulatory Authorities Intervene.

Standard 3: data monitoring committees.

Children are generally regarded as “vulnerable individuals.” There has long been reluctance to perform research in children except in limited settings such as pediatric cancer and vaccine development. However, avoidance of trials in children has resulted in uncertainty regarding efficacy, safety, appropriate formulations, and dosages of treatments in pediatric populations, a situation now recog...

Sleep in the Elderly – When to Reassure, When to Intervene

is determined solely by the Canadian Sleep Society Available online at www.insomniarounds.ca President Shelly K. Weiss, MD, FRCPC Hospital for Sick Children University of Toronto Toronto, ON Past President and Editor, Insomnia Rounds Helen S. Driver, PhD, RPSGT, DABSM Queen's University, Department of Medicine Sleep Disorders Laboratory, Kingston General Hospital Kingston, ON Vice-President, Re...

The ascending aortic aneurysm: When to intervene?

Thoracic trauma: when and how to intervene.

Trauma is the leading cause of death in patients younger than 40 years of age. Thoracic injuries are common and often can be managed by tube thoracostomy. In many patients, however, the thoracic injuries must be repaired surgically in one of three time periods: immediate, urgent, or delayed thoracotomy. In this article, we describe the general approach to effectively managing thoracic trauma pa...